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A high-performance liquid chromatographic method with amperometric detection for the determination of the diuretic indapamide using a µBondapak C 18  column is developed. The mobile phase consists of an acetonitrile–water mixture (45:55, 5mM) in KH 2 PO 4 –K 2 HPO 4  (pH 4.0). The compound is monitored at +1200 mV with an amperometric detector equipped with a glassy carbon working electrode. A liquid-liquid or solid-liquid extraction is performed prior to chromatographic analysis to avoid the interferences found in urine matrix. Percentages of recovery are 88.3 ± 5.6 and 82.9 ± 7.8 for liquid–liquid and solid–liquid extraction, respectively. The developed method has a linear concentration range from 25 to 315 ng/mL with a reproducibility in terms of relative standard deviation of 4% for a concentration level of 0.5 µg/mL and a quantitation limit of 1 ng/mL. The method is applied to the determination of indapamide in tablets and urine obtained from hypertensive patients after the ingestion of Tertensif (indapamide 2.5 mg).

Quantitative Determination of Indapamide in Pharmaceuticals and Urine by High-Performance Liquid Chromatography with Amperometric Detection