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The retention characteristics of 25 2-cyano-3-methylthio-3-substituted amine-acrylates are determined using reversed-phase thin-layer chromatography (RP-TLC) with methanol—water mixtures as eluents. The relationship between  R  m  values and partition coefficients ( C  log  P ) are established. The  R  m  values decrease linearly with increasing methanol concentration in the eluent. The  R  m  values extrapolated to zero organic modifier concentration ( R  m 0 ) in the eluent are highly related to  C  log  P . The R m0  value can be used to evaluate the lipophilicity of this kind of compound.

Lipophilicity Determination of Some Potential Photosystem II Inhibitors on Reversed-Phase High-Performance Thin-Layer Chromatography