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Capillary electrochromatography (CEC) is an emerging high-resolution separation technique that combines features of both capillary electrophoresis (CE) and micro-high-performance liquid chromatography (HPLC). CEC is capable of resolving neutral and ionic species with very high separation efficiencies because of its high selectivity and versatile properties. The difficulties in preparing reliable CEC columns and using CEC with regular CE instruments for routine analysis has limited its application. Nevertheless, many recent improvements of the technique, optimization of method development, and the potential use in pharmaceutical analysis and bioanalysis has made CEC a technique that is rapidly gaining acceptance.In this report, we have developed a CEC method for the rapid separation of a contraceptive drug substance, norgestimate, and its related degradation compounds. Total analysis time is reduced by more than 50% when compared with the current in-house HPLC method. The relative standard deviations for both the retention time and peak areas are less than 2%. Effects of other experimental parameters on the separation characteristics of norgestimate using CEC, such as effects of solvent composition, solvent strength, and buffer concentration, are discussed.

Rapid Analysis of Norgestimate and Its Potential Degradation Products by Capillary Electrochromatography