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An improved high-performance liquid chromatographic assay for the determination of procainamide and n-acetylprocainamide (NAPA) at concentrations observed up to 32 h after a single oral dose administration of procainamide to human subjects is reported. Following liquid—liquid extraction of plasma samples, procainamide, NAPA, and the internal standard ( N -propionylprocainamide) are separated on a reversed-phase C 8 column with retention times of 4.0, 6.7, and 13.2 min, respectively. The ultraviolet detection limit (wavelength, 280 nm) of procainamide and NAPA is 2 ng/mL (signal-to-noise ratio, 3:1), and the quantitation limit is 4 ng/mL (signal-to-noise ratio, 5:1). Intra- and interday coefficients of variation are less than 8% in the range of 20–500 ng/mL.

journal of chromatographic science

Improved High-Performance Liquid Chromatographic Assay for the Determination of Procainamide and Its  N -Acetylated Metabolite in Plasma: Application to a Single-Dose Pharmacokinetic Study