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Cortical layer 5B (L5B) thick-tufted pyramidal neurons have reliable responses towhisker stimulation in anesthetized rodents. These cells drive a corticothalamicpathway that evokes spikes in thalamic posterior medial nucleus (POm). While asubset of POm has been shown to integrate both cortical L5B and paralemniscalsignals, the majority of POm neurons are suggested to receive driving input fromL5B only. Here, we test this possibility by investigating the origin ofwhisker-evoked responses in POm and specifically the contribution of the L5B-POmpathway. We compare L5B spiking with POm spiking and subthreshold responses towhisker deflections in urethane anesthetized mice. We find that a subset ofrecorded POm neurons shows early (&lt;50 ms) spike responses and early largeEPSPs. In these neurons, the early large EPSPs matched L5B input criteria, wereblocked by cortical inhibition, and also interacted with spontaneous Up statecoupled large EPSPs. This result supports the view of POm subdivisions, one ofwhich receives whisker signals predominantly via L5B neurons.

Cortical Dependence of Whisker Responses in Posterior Medial Thalamus In Vivo