English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

A key step in the development of the cerebral cortex is a patterning process, which subdivides the telencephalon into several molecularly distinct domains and is critical for cortical arealization. This process is dependent on a complex network of interactions between signaling molecules of theFgfandWntgene families and theGli3transcription factor gene, but a better knowledge of the molecular basis of the interplay between these factors is required to gain a deeper understanding of the genetic circuitry underlying telencephalic patterning. Using DNA-binding and reporter gene assays, we here investigate the possibility thatGli3and these signaling molecules interact by directly regulating each other's expression. We show that Fgf signaling is required forWnt8benhancer activity in the cortical hem, whereas Wnt/β-catenin signaling repressesFgf17forebrain enhancer activity. In contrast, Fgf and Wnt/β-catenin signaling cooperate to regulateGli3expression. Taken together, these findings indicate that mutual interactions betweenGli3,Wnt8b, andFgf17are crucial elements of the balance between these factors thereby conferring robustness to the patterning process. Hence, our study provides a framework for understanding the genetic circuitry underlying telencephalic patterning and how defects in this process can affect the formation of cortical areas.

cerebral cortex

Direct Interactions Between               Gli3              ,               Wnt8b              , and               Fgfs               Underlie Patterning of the Dorsal Telencephalon