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Self-avoidance is a mechanism by which dendrites from the same neuron repel one another in order to establish uniform coverage of the dendritic field. The importance of self-avoidance for the development of complex arborization patterns has been highlighted by studies of  Drosophila  sensory and mouse retinal neurons. However, it is unclear whether branch patterning in the mammalian central nervous system is also governed by this strategy. We reduced  Satb2  expression in a population of layer II/III pyramidal neurons  in vivo  by RNA interference and found that the somas of  Satb2 -deficient neurons clumped together, and their dendrites failed to expand laterally but instead formed fascicles. Furthermore, experiments showed that reducing  Satb2  caused the adhesion of not only neighboring  Satb2 -deficient neurons but also neighboring wild-type neurons. Our results indicate a cell autonomous and non-cell autonomous role for  Satb2  in regulating the adhesive and/or repulsive properties of cerebral pyramidal neurons.

Satb2 Is Required for Dendritic Arborization and Soma Spacing in Mouse Cerebral Cortex