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Human precentral and postcentral cortical areas interact to generate sensorimotor functions. Recent imaging work suggests that pre- and postcentral cortical thicknesses of an individual vary over time-scales of years and decades due to aging, disease, and other factors. In contrast, there is little understanding of how thicknesses of these areas vary in an individual over time-scales of minutes and weeks. This study used longitudinal magnetic resonance imaging (MRI) and computational morphometry approaches in 5 healthy subjects to assess how mean thicknesses, and intra- and interhemispheric relationships in mean thicknesses, of these areas vary in an individual subject over minutes and weeks. Within each individual, absolute differences in thicknesses over these times were small and similar in the precentral (mean = 0.02–0.04 mm) and postcentral (mean = 0.03–0.05 mm) areas. Each individual also had a consistent intrahemispheric disparity and interhemispheric asymmetrical or symmetrical relationship in thicknesses of these areas over these times. The results provide new understanding of within-individual cortical thickness variability in these areas and raise the possibility that longitudinal thickness profiling can provide a baseline definition of short time-scale thickness variability that can be used to detect acute and subacute changes in pre- and postcentral thicknesses at an individual subject level.

Profiles of Precentral and Postcentral Cortical Mean Thicknesses in Individual Subjects over Acute and Subacute Time-Scales