English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

The apolipoprotein E ( APOE )  ε4  allele is the major genetic risk factor for Alzheimer's disease, but an  APOE  effect on memory performance and memory-related neurophysiology in young, healthy subjects is unknown. We found an association of  APOE ε4  with better episodic memory compared with  APOE ε2  and  ε3  in 340 young, healthy persons. Neuroimaging was performed in a subset of 34 memory-matched individuals to study genetic effects on memory-related brain activity independently of differential performance. E4 carriers decreased brain activity over 3 learning runs, whereas  ε2  and  ε3  carriers increased activity. This smaller neural investment of  ε4  carriers into learning reappeared during retrieval:  ε4  carriers exhibited reduced retrieval-related activity with equal retrieval performance.  APOE  isoforms had no differential effects on cognitive measures other than memory, brain volumes, and brain activity related to working memory. We suggest that  APOE ε4  is associated with good episodic memory and an economic use of memory-related neural resources in young, healthy humans.

Better Memory and Neural Efficiency in Young Apolipoprotein E ε4 Carriers