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The connectivity of cortical microcircuits is a major determinant of brain function; defining how activity propagates between different cell types is key to scaling our understanding of individual neuronal behavior to encompass functional networks. Furthermore, the integration of synaptic currents within a dendrite depends on the spatial organization of inputs, both excitatory and inhibitory. We identify a simple equation to estimate the number of potential anatomical contacts between neurons; finding a linear increase in potential connectivity with cable length and maximum spine length, and a decrease with overlapping volume. This enables us to predict the mean number of candidate synapses for reconstructed cells, including those realistically arranged. We identify an excess of potential local connections in mature cortical data, with densities of neurite higher than is necessary to reliably ensure the possible implementation of any given axo-dendritic connection. We show that the number of local potential contacts allows specific innervation of distinct dendritic compartments.

Excess Neuronal Branching Allows for Local Innervation of Specific Dendritic Compartments in Mature Cortex