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Recent studies in rodents have suggested that some cortical GABAergic interneurons arise within the neuroepithelium of the subcortical telencephalon then migrate dorsally into the cerebral cortex. These studies have relied heavily on short-term organotypic culture methods and on the analysis of mutant mice that die during the neonatal period. The purpose of this study is to ascertain directly whether cells labeled in the subcortical telencephalon  in vivo  differentiate into mature cortical interneurons and whether any cortical interneurons arise from the dorsal, cortical neuroepithelium. Mitotic cells within the neonatal cortex or subcortical telencephalon were labeled by focal injections of [ 3 H]thymidine into the brains of neonatal ferrets. The fates of labeled cells were assessed in mature animals 6 weeks later. Our results suggest that many cortical interneurons, but not cortical projection neurons, derive from the subcortical telencephalon. Conversely, cortical projection neurons, but few if any interneurons, are generated within the proliferative zones of the neocortex.

Distinct Origins of Neocortical Projection Neurons and Interneurons In Vivo