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Inhibition of sulfotransferases by pentachlorophenol, and siRNA knockdown of the  SULT1A1  gene in human kidney (HK-2) and human fibroblast (GM00637) cell lines reduce significantly the levels of aristolactam-DNA adducts and toxicities induced by aristolochic acid I and its metabolite,  N -hydroxyaristolactam I.

Sulfotransferase-1A1-dependent bioactivation of aristolochic acid I and N -hydroxyaristolactam I in human cells