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Differential responses to tamoxifen and letrozole shown with two different lesions in the estrogen–ER pathway in genetically engineered mice, RNA-seq demonstrated an association of immune-related gene expression with tamoxifen resistance, and letrozole was an effective alternative when tamoxifen resistance was present.

carcinogenesis

Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance