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This study demonstrates that the intronic  TP53  polymorphisms rs1642785 and rs17878362 impact on the formation of G4 structures, mRNA splicing and stability, and thus on the differential expression of isoform-specific transcripts of the  TP53  gene.

carcinogenesis

Impact of G-quadruplex structures and intronic polymorphisms rs17878362 and rs1642785 on basal and ionizing radiation-induced expression of alternative p53 transcripts