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Here, we found that deregulated FGFR4 expression appears to be one of the key drivers of the malignant phenotype of hepatoma/hepatocarcinoma cells. Accordingly, blockade of FGFR4-mediated signalling may be a promising therapeutic approach to antagonize aggressive behaviour of the cells.

Fibroblast growth factor receptor 4: a putative key driver for the aggressive phenotype of hepatocellular carcinoma