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The objective of the study was to characterize the mechanism(s) of resveratrol-mediated protection against estrogen-induced breast carcinogenesis. This study provides evidences that resveratrol epigenetically induces NRF2 and its downstream protective pathways in mammary tissues and inhibits estrogen-induced breast carcinogenesis.

Resveratrol inhibits estrogen-induced breast carcinogenesis through induction of NRF2-mediated protective pathways