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Gastric myofibroblasts normally exhibit a neuroendocrine-like phenotype characterized by calcium-dependent regulated exocytosis, dense-cored secretory vesicles and expression of neuroendocrine markers such as secretogranin-II and proenkephalin. This phenotype is lost in myofibroblasts from advanced gastric cancer.

The neuroendocrine phenotype of gastric myofibroblasts and its loss with cancer progression