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Mitochondrial dynamics, especially the fission mediator Drp1, play an important role in LMP2A-induced cell migration in gastric and breast cancer cells. We show that the Notch pathway regulates this fission since inhibitors of the pathway decrease both migration and the expression of Drp1.

Epstein–Barr virus latent membrane protein-2A alters mitochondrial dynamics promoting cellular migration mediated by Notch signaling pathway