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This study identified the MGMT direct reversal DNA repair protein as a target for disulfiram (an established drug for treatment of alcoholism) and support repurposing of disulfiram for enhancing the efficacy of anti-glioma alkylating agents.

carcinogenesis

Disulfiram is a direct and potent inhibitor of human O              6              -methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage