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Platelets play an important role in carcinogenesis. We have now discovered the mechanisms of platelet-stimulated colon cancer invasion. We have not only described major signalling pathways employed by cancer cells but also used proteomics for identification of biomarkers released during colon cancer-platelet interactions.

Mechanisms of platelet-stimulated colon cancer invasion: role of clusterin and thrombospondin 1 in regulation of the P38MAPK–MMP-9 pathway