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CXCR4 and αvβ6 are significantly associated with liver metastasis of CRC. αvβ6 is required for SDF-1/CXCR4-induced directional migration of CRC cells. SDF-1/CXCR4 axis upregulates αvβ6 expression via ERK/Ets-1 signaling pathway.

SDF-1/CXCR4 axis promotes directional migration of colorectal cancer cells through upregulation of integrin αvβ6