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Loss of miR-200b correlates with poor prognosis and aggressive clinical features in ESCC patients. The tumor suppressor effects of miR-200b in ESCC may be mediated by inhibition of Kindlin-2, a modulator of actin cytoskeleton, FA formation and cell invasiveness.

carcinogenesis

miR-200b suppresses invasiveness and modulates the cytoskeletal and adhesive machinery in esophageal squamous cell carcinoma cells via targeting Kindlin-2