English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

FAS is a cell surface receptor involved in apoptotic signal transmission and plays important roles in the etiology of cancer. The −1377G&gt;A and −670A&gt;G polymorphisms of theFASgene influence theFAStranscription and have been implicated in cancer risk. However, the results from the published studies on the association between these twoFASpolymorphisms and cancer risk are conflicting. To derive a more precise estimation of association between theFASpolymorphisms and risk of cancer, we performed a meta-analysis of 11 461 cancer cases and 12 708 controls from 34 published case–control studies for these two polymorphisms. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Overall, individuals with the −1377AA genotype were associated with higher cancer risk than those with the −1377GG (OR = 1.21, 95% CI: 1.08–1.36,P  heterogeneity = 0.062) or GA/GG (OR = 1.23, 95% CI: 1.10–1.36,P  heterogeneity = 0.060) genotypes, whereas the −670GG genotype had no effects on overall cancer risk. In the stratified analyses for the −1377G&gt;A polymorphism, there was a significantly increased risk of breast cancer but a significantly decreased risk of melanoma in a dominant model. Moreover, a significantly increased risk was observed among smokers in a recessive model (OR = 1.96, 95% CI: 1.55–2.49;P  heterogeneity = 0.528). Although some modest bias could not be eliminated, this meta-analysis suggested that theFAS−1377A allele is a low-penetrant risk factor for cancer development, particularly among smokers.

FAS promoter polymorphisms and cancer risk: a meta-analysis based on 34 case–control studies