English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Background:The manganese superoxide dismutase (MnSOD) gene encodes an antioxidant enzyme (SOD2) that may protect cells from oxidative damage. The MnSOD allele withValas amino acid 16 encodes a protein that has 30–40% lower activity compared with theMnSOD Alavariant, hence possibly increasing susceptibility to oxidative stress. On the other hand, some epidemiologic studies suggest that theAlaallele is associated with a higher risk of cancer, including prostate cancer.Methods:We conducted a nested case–control study in the Health Professionals Follow-up Study with 612 incident prostate cancer cases and 612 matched controls to investigate the role of theMnSODgeneAla16Valpolymorphism and its joint association with plasma carotenoid concentrations in relation to risk of total prostate cancer and aggressive prostate cancer (advanced stage or Gleason sum ≥7).Results:The allele frequencies in the controls were 49.8% forAlaand 50.2% forVal. No association was found between theMnSODgenotype and risk of total and aggressive prostate cancer. Furthermore, no statistically significant interaction was observed between theMnSODgenotype and any of the plasma carotenoids in relation to risk of total and aggressive prostate cancer. In analyses in which we combined data from plasma and dietary carotenoids and created a quintile score to reflect long-term carotenoid status, a 3-fold [95% confidence interval: 1.37–7.02] increased risk of aggressive prostate cancer was observed among men with theAla/Alagenotype in the presence of low long-term lycopene status (P-value, test for interaction = 0.02) as compared with men with theAla/Val+Val/Valgenotypes with low long-term lycopene status.Conclusion:In this cohort of mainly white men, theMnSODgeneAla16Valpolymorphism was not associated with total or aggressive prostate cancer risk. However, men with theMnSOD  Ala/Alagenotype who had low long-term lycopene status had a higher risk of aggressive prostate cancer compared with individuals with the other genotypes. These results are consistent with findings from earlier studies that reported when antioxidant status is low, theMnSOD  Ala/Alagenotype may be associated with an increased risk of aggressive prostate cancer.

Manganese superoxide dismutase (MnSOD) gene polymorphism, interactions with carotenoid levels and prostate cancer risk