English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Intake of dietary factors that serve as methyl group donors may influence promoter hypermethylation in colorectal carcinogenesis. We investigated whether dietary folate, vitamin B2 and vitamin B6, methionine and alcohol were associated with mutL homologue 1 (MLH1) hypermethylation and the related molecular phenotypes of MLH1 protein expression, microsatellite instability (MSI) andBRAFmutations in patients with colorectal carcinomas. Within the Netherlands Cohort Study on diet and cancer (n= 120 852), 648 cases (367 men and 281 women) and 4059 subcohort members were available for data analyses from a follow-up period between 2.3 and 7.3 years after baseline. Gender-specific adjusted incidence rate ratios (RRs) were calculated over categories of dietary intake in case-cohort analyses. The intakes of folate, vitamin B2, methionine and alcohol were not associated with risk of tumors showingMLH1hypermethylation, those lacking MLH1 protein expression or with MSI. Among men, we observed strong positive associations between folate andBRAF-mutated tumors (RR = 3.04 for the highest versus lowest tertile of intake,P  trend= 0.03) and between vitamin B6 and tumors showingMLH1hypermethylation (highest versus lowest tertile: RR = 3.23,P  trend= 0.03). Among women, the relative risks of tumors withBRAFmutations orMLH1hypermethylation were also increased in the highest tertiles of folate and vitamin B6 intake, respectively, but these did not reach statistical significance. The positive associations between folate intake and tumors harboringBRAFmutations and between vitamin B6 intake and those showingMLH1hypermethylation were most pronounced among men and may suggest that these vitamins enhance colorectal cancer risk through genetic as well as epigenetic aberrations.

carcinogenesis

Associations of dietary methyl donor intake with               MLH1               promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer