English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Common genetic variants in cancer-related genes contribute to breast cancer. The innate immune system plays a crucial role in the immune surveillance against malignancies, thus it is plausible that genetic variations in key genes of the innate immunity such as the mannose-binding lectin (MBL),MBL2, could influence the risk for breast cancer. We investigated the association ofMBL2genotypes with breast cancer and conducted a comprehensive genotype and haplotype analysis of 26MBL2single nucleotide polymorphisms (SNPs) in a case–control study of breast cancer [166 African-American (AA) case patients versus 180 controls and 127 Caucasian (CAU) case patients versus 137 controls]. We observed that the A allele of the 3′-UTR SNP Ex4-1067 (NCBI SNP ID: rs10824792) was significantly associated with a decreased disease risk in AA women [odds ratio (OR) = 0.47, 95% confidence interval (CI) = 0.27–0.81]. Haplotype analysis ofMBL2showed that the frequency of the corresponding 3′ haplotype TATAAC (Ex4-1483, Ex4-1067, Ex4-1047, Ex4-901, Ex4-710, 3238bp 3′ STP) was lower in cases than controls among AA women (0.15 versus 0.21;P= 0.02) suggesting a protective effect after adjusting for covariates (OR = 0.51, 95% CI = 0.29–0.88,P= 0.018). In conclusion, this study presents preliminary evidence that common genetic variants in the 3′-UTR ofMBL2might influence the risk for breast cancer in AA women, probably in interaction with the 5′ secretor haplotypes that are associated with high concentrations of MBL.

carcinogenesis

The mannose-binding lectin (              MBL2              ) haplotype and breast cancer: an association study in African-American and Caucasian women