English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

We investigated association between polymorphisms in DNA repair genes and the capacity to repair DNA damage induced by γ-irradiation and by base oxidation in a healthy population. Irradiation-specific DNA repair rates were significantly decreased in individuals withXRCC1Arg399Gln homozygous variant genotype (0.45 ± 0.47 SSB/109Da) than in those with wild-type genotype (1.10 ± 0.70 SSB/109Da,P= 0.0006, Mann–WitneyU-test). The capacity to repair oxidative DNA damage was significantly decreased among individuals withhOGG1Ser326Cys homozygous variant genotype (0.37 ± 0.28 SSB/109Da) compared to those with wild-type genotype (0.83 ± 0.79 SSB/109Da,P= 0.008, Mann–WitneyU-test). Investigation of genotype combinations showed that the increasing number of variant alleles for bothXRCC1Arg399Gln andAPE1Asn148Glu polymorphisms resulted in a significant decrease of irradiation-specific repair rates (P= 0.008, Kruskal–Wallis test). Irradiation-specific DNA repair rates also decreased with increasing number of variant alleles inXRCC1Arg399Gln in combination with variant alleles for two otherXRCC1polymorphisms, Arg194Trp and Arg280His (P= 0.002 andP= 0.005, respectively; Kruskal–Wallis test). In a binary combination variant alleles ofhOGG1Ser326Cys andAPE1Asn148Glu polymorphisms were associated with a significant decrease in the capacity to repair DNA oxidative damage (P= 0.018, Kruskal–Wallis test). In summary,XRCC1Arg399Gln andhOGG1Ser326Cys polymorphisms seem to exert the predominant modulating effect on irradiation-specific DNA repair capacity and the capacity to repair DNA oxidative damage, respectively.

Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects