English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

STK15/Aurora-A is a centrosome-localized serine/threonine kinase that functions primarily in centrosome maturation and mitotic spindle assembly. In a large lung cancer case–control study of 1401 cases and 1397 controls including three ethnic groups, we examined the associations between two non-synonymous SNPs (Phe31Ile and Val57Ile) of the STK15 gene and lung cancer risk. There were statistically significant differences in the distribution of the genotypes (P&lt; 0.0001) and haplotypes (P&lt; 0.0001) by ethnicity for the Phe31Ile, but not the Val57Ile variant. Caucasians with the homozygous variant Phe31Ile genotype (Ile/Ile) were at a significantly reduced risk for lung cancer [odds ratio (OR) = 0.63, 95% confidence interval (CI) = 0.41–0.96]. The variant allele of Val57Ile was not associated with lung cancer risk overall. However, men with the homozygous variant genotype (Ile/Ile) had a reduced lung cancer risk as compared with men with the wild-type genotype (Val/Val) (OR = 0.42, 95% CI = 0.19–0.94). When we performed joint analysis of these two polymorphisms, compared with the reference group (TT + GG, 40.99% of controls), homozygous Ile31 allele/wild-type Val57 allele (AA + GG) carriers (5.45% of controls) exhibited a reduced lung cancer risk (OR = 0.78, 95% CI = 0.63–0.97). This is the first epidemiological study to report significant associations between STK15 polymorphisms and lung cancer risk.

Polymorphisms of STK15 (Aurora-A) gene and lung cancer risk in Caucasians