English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Studies investigating the association between cytochrome P450 2E1 (CYP2E1) 5′-flanking region (PstI/RsaI) polymorphism and gastric cancer risk report conflicting results. The rationale for this meta-analysis was to determine whetherCYP2E1  *2 (c2) variant allele ofCYP2E1increases gastric cancer risk, especially by interacting with smoking, alcohol and other metabolic gene polymorphisms. Two investigators independently searched the Medline and Embase databases. A qualitative scoring of papers was applied to their evaluation. Authors of the identified papers were contacted to obtain data on the mentioned co-exposures. A measurement of the biological interaction among two putative risk factors was estimated by the attributable proportion (AP) due to interaction. We identified 13 case–control studies, which included 2066 gastric cancer cases and 2754 controls. Using the random effects model, we found no association betweenPstI/RsaI genotype and gastric cancer risk [odds ratio (OR) = 0.97 (95% confidence interval (CI): 0.79–1.18) for c2 allele carriers and OR = 1.36 (95% CI: 0.82–2.25) for c2 homozygotes compared with homozygotes wild-type]. When only high-quality scored studies were considered, a statistically significant increased risk appeared among Asians [OR = 1.50 (95% CI: 1.16–1.94) for c2 carriers and OR = 2.62 (95% CI: 1.23–5.57) for c2 homozygotes]. No interaction was detected betweenCYP2E1-smoking/alcohol (AP = 0), while an AP of 60% appeared for individuals both c2 homozygotes and glutathioneS-transferaseM1 (GSTM1)null compared with both homozygotes wild-type. This meta-analysis suggests that theCYP2E1 PstI/RsaI polymorphism may be a risk factor for gastric cancer in Asians, and that a synergic relation amongGSTM1andCYP2E1may account for a proportion of gastric cancer cases.

carcinogenesis

CYP2E1Pst              I/              Rsa              I polymorphism and interaction with tobacco, alcohol and               GST              s in gastric cancer susceptibility: a meta-analysis of the literature