English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

The MDM2 protein negatively regulates p53 expression level in modulating DNA repair, cell-cycle control, cell growth and apoptosis. Polymorphisms in the promoter region of theMDM2gene have been shown to alter protein expression and may, thus, play a role in carcinogenesis. To test our hypothesis that theMDM2promoter polymorphisms are associated with risk of lung cancer, we conducted a hospital-based, case–control study of 1026 non-Hispanic white patients newly diagnosed with lung cancer and 1145 cancer-free controls who were frequency-matched by age (±5 years), sex, ethnicity and smoking status. We genotyped for theMDM2promoter G2580T (also called SNP309) and G2164A polymorphisms that have a minor allele frequency &gt;0.05. The distributions of theMDM2-2580G variant allele and genotypes were significantly less common among the cases than among the controls (P= 0.038 and 0.045, respectively), but this was not evident forMDM2-2164G (P= 0.865 and 0.614, respectively). Compared with theMDM2-2580TT genotype, theMDM2-2580G variant genotypes were associated with a decreased risk of lung cancer [odds ratio = 0.81 and 95% confidence interval = 0.67–0.98 for GT, 0.83 (0.63-1.08) for GG, and 0.81 (0.68-0.97) for the combined GT/GG genotype]. However, no significant association was observed between theMDM2-2164G variant genotypes and lung cancer risk. Our results suggest that theMDM2-2580G allele may be a marker of reduced genetic susceptibility to lung cancer in the non-Hispanic white population, a finding that seems to contradict previous reports.

MDM2 gene promoter polymorphisms and risk of lung cancer: a case–control analysis