English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

In addition to environmental exposures like UV radiation and, in some cases, arsenic contamination of drinking water, genetic factors may also influence the individual susceptibility to basal cell carcinoma of skin (BCC). In the present study, 529 cases diagnosed with BCC and 533 controls from Hungary, Romania and Slovakia were genotyped for one polymorphism in each of seven DNA repair genes. The variant allele for T241M (C&gt;T) polymorphism in theXRCC3gene was associated with a decreased cancer risk [odds ratio (OR), 0.73; 95% confidence interval (CI), 0.61–0.88;P= 0.0007, multiple testing correctedP= 0.004]. The risk of multiple BCC was significantly lower among variant allele carriers than in non-carriers (P= 0.04). Men homozygous for the C-allele for E185Q (G&gt;C) polymorphism in theNBS1gene showed an increased BCC risk (OR, 2.19; 95% CI, 1.23–3.91), but not women (OR, 0.84; 95% CI, 0.49–1.47). In men, the age and nationality adjusted OR for the genotype CC (XRCC3)/CC (NBS1) was 8.79 (95% CI, 2.10–36.8), compared with the genotype TT (XRCC3)/GG (NBS1). The data from this study show overall risk modulation of BCC by variant allele for T241M polymorphism inXRCC3and gender-specific effect by E185Q polymorphism inNBS1.

Single nucleotide polymorphisms in DNA repair genes and basal cell carcinoma of skin