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It is well-established that a high incidence of p53 mutations exist in oralcavity squamous cell carcinomas (OCSCCs). To determine whether p53 mutations areetiologically associated with OCSCC development or are associated with exposureto specific carcinogens, we have analyzed the conserved regions of thep53  gene(exons 5-9) in 48 OCSCCs obtained from patientswith varied tobacco and alcohol use histories by polymerase chainreaction/single strand conformational polymorphism (PCR/SSCP) andDNA sequencing analysis. Thirty-eight percent (18/48) of the OCSCCsexhibited a mutation in exons 5-9 of the  p 53 gene. There was asignificantly higher incidence of p53 mutationsin OCSCCs from tobacco users(predominantly cigarette smokers) compared to those who had never used tobacco.No increase in the incidence of p53 mutation was observed in tobacco users whodrank alcohol. G to A transitions and deletions were thepredominant mutationsobserved in OCSCCs from tobacco users. No specific pattern of mutation wasobsered in OCSCCs from those subjects who had never used tobacco. These datasuggest that a history of tobacco use was associated with a high incidence ofp53 mutations in patients with OCSCC and that tobacco carcinogens induce aspecific pattern of mutations in oral cavity tissue  invivo .

Relationship between p53 mutation incidence in oral cavity squamous cell carcinomas and patient tobacco use