English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

To evaluate the toxic effects of prolonged exposure to chloroform vapors, femaleand male F344 rats were exposed to 0, 2, 10, 30, 90 and 300 p.p.m. chloroform byinhalation for 7 or 5 days/week for up to 13 weeks. The purpose of thisstudy was to characterize a lesion that occurred in the livers of rats in the300 p.p.m. exposure groups. Atypical glandular structures lined byintestinal-like epithelium and surrounded by dense connective tissue occurred inthe livers of ratsexposed to strongly hepatotoxic atmospheric concentrations ofchloroform. Bile duct bromodeoxyuridine labeling indices as well as observationsof the locations of the early lesions at the 3 and 6 week time points indicatethat these lesions arose from a population of cells remote from bile ducts. Werefer to these lesions as intestinal crypt-like ducts with periductular fibrosisto distinguish them from true cholangiofibrosis. Here, intestinal crypt-likeducts with periductular fibrosis were seen only in rats exposed to 300 p.p.m.chloroform, and the multiplicity and severity of the lesions were greaterin theright liver lobe. The lesion only occurred in association with liver necrosisand dramatic increases in hepatocyte labeling indices, while labeling indices inbile ducts in the same animals were not significantly different fromcontrols.There was a treatment-related increase of transforming growthfactor-α immunoreactivity in hepatocytes, bile duct epithelium, bilecanaliculi and oval cells, and an increase in transforming growthfactor-β immunoreactivity in hepatocytes, bile duct epithelium andintestinal crypt-like ducts. Thus, intestinal crypt-like ducts with periductularfibrosis appeared to develop from a population of cells unrelated to bile ducts.Also, they occurred only in animals exposed to chloroform concentrations thatinduced significant hepatocyte necrosis and regenerative cell proliferation andwere associated with increased growth factor expression or uptake.

carcinogenesis

A non-bile duct origin for intestinal crypt-like ducts with                     periductular fibrosis induced in livers of F344 rats by chloroform                     inhalation