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The present studies compared the effects of various oil-soluble compoundscontaining allyl and disulfide groups on the proliferation of cultured humancolon tumor cells (HCT-15). Diallyl disulfide (DADS) was more effective ininhibiting the growth of HCT-15 cells than isomolar concentrations of S-allylcysteine, dipropyl disulfide (DPDS), allyl chloride, allyl glycidyl ether andallyl alcohol. These studies clearly demonstrate the importance of both thediallyl and the disulfide groups in DADS. Treatment of HCT-15 cells with 100μM DADS increased the intracellular calcium levels by 40%,whileDPDS caused only a 12% increase in intracellular calcium. Exposure to 100μM DADS or more, but not DPDS, caused the cells to undergo apoptosis asdetermined by morphological changes and DNA fragmentation. A positivecorrelation ( r  = 0.944) was found between DADS-inducedDNA fragmentation and its ability to increase intracellular free calcium levels.The widespread effectiveness of DADS was evident by its ability to inhibit thegrowth of human colon (HCT-15), skin (SKMEL-2) and lung (A549) tumor celllines.

Diallyl disulfide induces apoptosis of human colon tumor cells