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Mutation induction in the  supF  gene of the plasmid pS189 by 7-bromomethylbenz[ a ]anthracene and 7-bromomethyl-12–7-bromomethylbenz[ a ]anthracene was examined. The former compound was substantially more mutagenic than the latter but a much greater proportion of the total mutations were located at mutation hotspots for the 12-methyl derivative. The overall correlation between sites of mutation and sites of polymerase arrest (anindicator of adduct formation) through the  supF  gene was poor. Although these bromo-compounds should formonly a single guanine adduct (unlike dihydrodiol epoxides that from both  cis  and  trans adducts) more than one mutational change was found at a given site, although the predominant base substitution was G→for either compound.

Mutagenic specificities and adduct distributions for 7-bromomethylbenz[ a ]anthracenes