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Aim The main goal of the present work is to study and ability of Atomic Layer Depostion (ALD) ultra-thin (&amp;lt;100nm) ceramic films on polypropylene (PP) hernia meshes to prevent the mesh-associated infections (post-surgery complications). Material and Methods Three types of ALD nanofilms were examined: Al2O3, TiO2, or TixVyOz. 10 rats and 5 rabbits were used to evaluate the tissue reaction of surface modified PP meshes and for biomechanical (antibacterial, inflammation effect), biocompatibility, and barrier testing of the healed tissue. The ALD coated PP meshes were implanted into rabbits and rats together with uncoated ones. After 10, 20, 30 and 60 days, the hernia meshes with the surrounding soft tissues were removed and fixed for histological and cytological studies. Results The TixVyOz (28nm) film showed enhanced antibacterial activity compare to Al2O3 and TiO2 films. The histology was performed on coated and uncoated PP mesh samples. Conclusions The ALD TixVyOz film helped to avoids formation of rough scar tissue (microscale roughness, which prevents ability biofilm formation) and, reduction of eosinophilic-cell and lymphocytic-cell reactions of the tissues surrounding the mesh, illustrate good integration into the surrounding tissue with minimal inflammatory reaction and minimal adhesions to intra-abdominal structures. The ALD film was highly effective in inhibiting S. aureus and E. coli bacteria adhesion and exhibited excellent biological activity in promoting osteoblastic adhesion. Speculatively, presence of vanadyl (≡V=O:) chemical groups, either on the surface or in the bulk, believe to play a key role in high performance of the TixVyOz compare to TiO2.

P040 INFLAMMATORY REACTION TO ALD COATED POLYPROPYLENE MESHES USED FOR HERNIA REPIAR. AN EXPERIMENTAL STUDY IN ANIMALS