Open AccessFinding prokaryotic genes by the ‘frame-by-frame’ algorithm: targeting gene starts and overlapping genes
Author(s) -
A. M. Shmatkov,
Arik Melikyan,
F. L. Chernousko,
Mark Borodovsky
Publication year - 1999
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/15.11.874
Subject(s) - gene prediction , orfs , gene , annotation , open reading frame , genome , genetics , computational biology , biology , genome project , computer science , algorithm , gene annotation , peptide sequence
Tightly packed prokaryotic genes frequently overlap with each other. This feature, rarely seen in eukaryotic DNA, makes detection of translation initiation sites and, therefore, exact predictions of prokaryotic genes notoriously difficult. Improving the accuracy of precise gene prediction in prokaryotic genomic DNA remains an important open problem.
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