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This article offers a briefing in one of the knowledge management issues of  in silico  experimentation in bioinformatics. Recording of the  provenance  of an experiment—what was done; where, how and why, etc. is an important aspect of scientific best practice that should be extended to  in silico  experimentation. We will do this in the context of eScience which has been part of the move of bioinformatics towards an industrial setting. Despite the computational nature of bioinformatics, these analyses are scientific and thus necessitate their own versions of typical scientific rigour. Just as recording who, what, why, when, where and how of an experiment is central to the scientific process in laboratory science, so it should be  in silico  science. The generation and recording of these aspects, or provenance, of an experiment are necessary knowledge management goals if we are to introduce scientific rigour into routine bioinformatics.  In Silico  experimental protocols should themselves be a form of managing the knowledge of how to perform bioinformatics analyses. Several systems now exist that offer support for the generation and collection of provenance information about how a particular  in silico  experiment was run, what results were generated, how they were generated, etc. In reviewing provenance support, we will review one of the important knowledge management issues in bioinformatics.

Using provenance to manage knowledge of In Silico experiments