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Occupational exposure to cytotoxic drugs has frequently been reported during recent years. Various drug-handling systems have been applied to reduce the spill and leakage that cause this exposure. Some of these systems have also been tested for spill and leakage using independent test methods. In this paper, a new drug-handling system has been tested for spill and leakage during drug preparation. The handling system, Tevadaptortrade mark, was tested using a modification of an independent test method, the Technetium test method, based on the use of Technetium m-99 as tracer substance. The test results showed that the spill was &lt;100 nl for all 75 preparations and was &lt;1 nl for 70 of the preparations. This is comparable with other tested drug-handling system, e.g. isolators, PhaSealtrade mark. The test shows that the Tevadaptor drug-handling system has similar performance as drug-handling systems regarded as closed systems.

Spill and Leakage Using a Drug Preparation System Based on Double-Filter Technology