Open AccessMore Alcohol, More Liver Injury: Not Always True
Author(s) -
Irina Kirpich,
Craig J. McClain
Publication year - 2017
Publication title -
alcohol and alcoholism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.747
H-Index - 99
eISSN - 1464-3502
pISSN - 0735-0414
DOI - 10.1093/alcalc/agx064
Subject(s) - metabolome , alcohol , alcoholic liver disease , liver injury , alcohol and health , alcohol tolerance , microbiome , ethanol , medicine , liver disease , gut microbiome , animal model , physiology , biology , bioinformatics , biochemistry , alcohol consumption , metabolite , cirrhosis
An animal model of alcoholic liver disease (ALD) that recapitulates human disease is an unmet need. An alcohol-preferring strain and WT mice were fed alcohol by different techniques and with different diet compositions. Interestingly, the greatest alcohol consumers did not develop the worst ALD. This editorial highlights how diet and the gut microbiome/metabolome may influence the development/severity of ALD.
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