Open AccessMajor Anaerobic Bacteria Responsible for the Production of Carcinogenic Acetaldehyde from Ethanol in the Colon and Rectum
Author(s) -
Atsuki Tsuruya,
Akika Kuwahara,
Yuta Saito,
Haruhiko Yamaguchi,
Natsuki Tenma,
Makoto Inai,
Seiji Takahashi,
Eri Tsutsumi,
Yoshihide Suwa,
Yukari Totsuka,
Wataru Suda,
Kenshiro Oshima,
Masahira Hattori,
Takeshi Mizukami,
Akira Yokoyama,
Takefumi Shimoyama,
Tôru Nakayama
Publication year - 2016
Publication title -
alcohol and alcoholism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.747
H-Index - 99
eISSN - 1464-3502
pISSN - 0735-0414
DOI - 10.1093/alcalc/agv135
Subject(s) - acetaldehyde , obligate anaerobe , obligate , microbiology and biotechnology , biology , carcinogen , anaerobic bacteria , aerobic bacteria , bacteria , anaerobic exercise , ethanol , biochemistry , physiology , ecology , genetics
The importance of ethanol oxidation by intestinal aerobes and facultative anaerobes under aerobic conditions in the pathogenesis of ethanol-related colorectal cancer has been proposed. However, the role of obligate anaerobes therein remains to be established, and it is still unclear which bacterial species, if any, are most important in the production and/or elimination of carcinogenic acetaldehyde under such conditions. This study was undertaken to address these issues.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom