Open AccessMelatonin Upregulates the Activity of AMPK and Attenuates Lipid Accumulation in Alcohol-induced Rats
Author(s) -
Bei-bei Rui,
Hao Chen,
Lei Jang,
Zhen Li,
Jing-mo Yang,
Weiping Xu,
Wei Wei
Publication year - 2015
Publication title -
alcohol and alcoholism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.747
H-Index - 99
eISSN - 1464-3502
pISSN - 0735-0414
DOI - 10.1093/alcalc/agv126
Subject(s) - melatonin , medicine , endocrinology , ampk , luzindole , malondialdehyde , chemistry , lipid peroxidation , alcoholic fatty liver , fatty liver , melatonin receptor , protein kinase a , oxidative stress , kinase , biochemistry , disease
Melatonin is supposed to be an effective hepatoprotective agent. The effects and mechanisms of melatonin on alcoholic fatty liver (AFL) have not been well explored. The aim of this study was to investigate the preventive and therapeutic effects of melatonin on alcohol-induced fatty liver rats.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom