Open AccessAcute Alcohol-Induced Decrease in Muscle Protein Synthesis in Female Mice Is REDD-1 and mTOR-Independent
Author(s) -
Jennifer L. Steiner,
Scot R. Kimball,
Charles H. Lang
Publication year - 2015
Publication title -
alcohol and alcoholism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.747
H-Index - 99
eISSN - 1464-3502
pISSN - 0735-0414
DOI - 10.1093/alcalc/agv105
Subject(s) - endocrinology , medicine , p70 s6 kinase 1 , autophagy , pi3k/akt/mtor pathway , protein degradation , ubiquitin , anabolism , mtorc1 , skeletal muscle , chemistry , protein kinase a , biology , phosphorylation , signal transduction , biochemistry , apoptosis , gene
To determine the causative role of the REDD (regulated in development and DNA damage)-1 protein, a known negative regulator of mTOR kinase, in changes in muscle protein synthesis induced by acute alcohol administration.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom