Open AccessGlycosylation Changes in the Salivary Glycoproteins of Alcohol-Dependent Patients: A Pilot Study
Author(s) -
Ewa Maria Kratz,
Napoleon Waszkiewicz,
Anna Kałuża,
Sławomir Dariusz Szajda,
Beata ZalewskaSzajda,
Agata Szulc,
Krzysztof Zwierz,
Mirosława Ferens-Sieczkowska
Publication year - 2013
Publication title -
alcohol and alcoholism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.747
H-Index - 99
eISSN - 1464-3502
pISSN - 0735-0414
DOI - 10.1093/alcalc/agt152
Subject(s) - fucosylation , glycoprotein , glycosylation , sialic acid , glycan , lectin , transferrin , fucose , saliva , biochemistry , chemistry , epitope , antigen , microbiology and biotechnology , biology , immunology
Glycosylation of serum proteins is affected with prolonged heavy drinking, and carbohydrate deficient transferrin (CDT) is well established and highly specific biomarker of sustained alcohol consumption. However, total amount of sialic acid is not the only glycoepitope that may be altered as a result of the disease. This work is focused on glycan structures altered in salivary glycoproteins of alcoholics, indicating the most efficient carriers of such marker glycoepitopes.
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