Open AccessInsulin Resistance, Ceramide Accumulation and Endoplasmic Reticulum Stress in Experimental Chronic Alcohol-Induced Steatohepatitis
Author(s) -
Teresa González Ramírez,
Lisa Longato,
Miroslav Dostálek,
Ming Tong,
Jack R. Wands,
Suzanne M. de la Monte
Publication year - 2012
Publication title -
alcohol and alcoholism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.747
H-Index - 99
eISSN - 1464-3502
pISSN - 0735-0414
DOI - 10.1093/alcalc/ags106
Subject(s) - insulin resistance , steatohepatitis , ceramide , unfolded protein response , endocrinology , insulin receptor , medicine , biology , protein kinase b , endoplasmic reticulum , irs1 , oxidative stress , lipid metabolism , fatty liver , insulin , biochemistry , signal transduction , apoptosis , disease
Chronic alcohol abuse causes steatohepatitis with insulin resistance, which impairs hepatocellular growth, survival and metabolism. However, growing evidence supports the concept that progressive alcohol-related liver injury may be mediated by concurrent mal-signaling through other networks that promote insulin resistance, e.g. pro-inflammatory, pro-ceramide and endoplasmic reticulum (ER) stress cascades.
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