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lar diseases and their fatal complications. Pregnancy proteins are new and nontraditional markers related to vascular damage and cardiovascular risk. Pregnancy-associated plasma protein A (PAPP-A) is a zinc-binding metalloproteinase and placental growth factor (PlGF) is a member of the vascular endothelial growth factor family. The aim of the study was to evaluate PAPP-A and PlGF in patients with chronic alcohol abuse and their change after 3 months hospital inpatient alcohol treatment based on group and individual therapy. Methods. The studied group consisted of 11 patients with chronic alcohol abuse (7 men and 4 women, mean age 38 ± 8 years). A group of healthy controls was used for comparison. PAPP-A was measured by TRACE (timeresolved amplified cryptate emission) and PlGF by ELISA (enzyme-linked immunosorbent assay). Results. PlGF was significantly increased in chronic alcoholics before treatment compared with controls (12.4 ± 3.1 vs. 8.1 ± 1.8 pg/ml, P < 0.0001) and decreased significantly after the treatment (9.3 ± 2.8 pg/ml, P = 0.014 vs. before treatment, not significant vs. controls). PAPP-A did not differ between alcoholics and controls and was not influenced by the treatment (10.5 ± 3.7 mIU/l before treatment, 10.5 ± 3.1 mIU/l after treatment, 9.5 ± 2.4 mIU/l in controls). PlGF in alcoholics did not correlate with PAPP-A, neither before nor after treatment. Conclusion. PlGF, a new marker related to cardiovascular risk, is significantly increased in chronic alcoholics and decreases after 3 months hospital inpatient alcohol treatment to similar levels as in healthy subjects. Further studies are required to evaluate new biomarkers in patients with chronic alcohol abuse, their changes during therapy and thus their possible usage in risk evaluation. Acknowledgement The study was supported by research projects MSM 0021620807 and MZO 0000VFN2005.

alcohol and alcoholism

FREE ORAL COMMUNICATIONS 7: SUBGROUPS OF ALCOHOL DEPENDENCE AND THEIR SPECIAL TREATMENT * O7.1 * ALCOHOL DEPENDENCE: LINKING GENES WITH INTERMEDIATE NEUROBIOLOGICAL PHENOTYPES