Open AccessDo Alcohol-dependent Individuals with DRD2 A1 Allele Have an Increased Risk of Relapse? A Pilot Study
Author(s) -
Angelica Dahlgren,
HannaLinn Wargelius,
Kristina Berglund,
Claudia Fahlke,
Kaj Blennow,
Henrik Zetterberg,
Lars Oreland,
Ulf Berggren,
Jan Balldin
Publication year - 2011
Publication title -
alcohol and alcoholism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.747
H-Index - 99
eISSN - 1464-3502
pISSN - 0735-0414
DOI - 10.1093/alcalc/agr045
Subject(s) - allele , alcohol , alcohol dependence , medicine , oncology , psychology , psychiatry , pharmacology , genetics , biology , gene , biochemistry
The TaqIA polymorphism of the dopamine D2 receptor (DRD2) gene has been extensively studied in relation to alcoholism, and the TaqI A1 allele appears to be over-represented in alcohol-dependent individuals. In a recent study, this allele has also been associated with a highly increased mortality rate in alcohol-dependent individuals. In the present study, we investigated whether the TaqI A1 allele of the DRD2 gene region was associated with a higher relapse rate in alcohol-dependent individuals.
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