Open AccessCHRONIC ETHANOL CONSUMPTION DECREASES MITOCHONDRIAL AND GLYCOLYTIC PRODUCTION OF ATP IN LIVER
Author(s) -
Tracey Young,
Shan M. Bailey,
Cynthia G. Van Horn,
Carol Cunningham
Publication year - 2006
Publication title -
alcohol and alcoholism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.747
H-Index - 99
eISSN - 1464-3502
pISSN - 0735-0414
DOI - 10.1093/alcalc/agl017
Subject(s) - glycolysis , ethanol , mitochondrion , consumption (sociology) , medicine , biochemistry , chemistry , endocrinology , metabolism , philosophy , aesthetics
The synthesis of ATP in the liver of the chronic ethanol consumer is suppressed, particularly if the tissue becomes hypoxic. Moreover, the perivenous region of the liver lobule becomes even more oxygen deficient as a result of ethanol consumption. Synthesis of ATP in the perivenous region of the lobule may be depressed in the chronic ethanol consumer due to decreases in both mitochondrial and glycolytic activities. In this study the effects of hypoxia on hepatic ATP levels derived from synthesis by both oxidative phosphorylation and the glycolytic mechanisms were investigated.
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