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Micro-injections (10 nmol/day over 5 days) of antisense oligodeoxynucleotides (aODNs) to gamma-aminobutyric acid A (GABA(A)) receptor alpha1 and gamma2 subunits reduce the mRNA for these subunits in rat brain. In this study, the effects of alpha1 and gamma2 subunit aODNs on rat alcohol preference were investigated. Reduction of the alpha1 subunit mRNA decreased, whereas reduction of the gamma2 subunit mRNA increased, ethanol intake in rats.

Changes in ethanol preference by rats treated with gamma1 and gamma2 GABAA receptor subunit antisense oligodeoxynucleotides