Open AccessChanges in ethanol preference by rats treated with gamma1 and gamma2 GABAA receptor subunit antisense oligodeoxynucleotides
Author(s) -
Ewa Malatyńska
Publication year - 2001
Publication title -
alcohol and alcoholism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.747
H-Index - 99
eISSN - 1464-3502
pISSN - 0735-0414
DOI - 10.1093/alcalc/36.4.309
Subject(s) - gabaa receptor , protein subunit , ethanol , messenger rna , receptor , endocrinology , chemistry , medicine , alcohol , conditioned place preference , pharmacology , biochemistry , biology , gene
Micro-injections (10 nmol/day over 5 days) of antisense oligodeoxynucleotides (aODNs) to gamma-aminobutyric acid A (GABA(A)) receptor alpha1 and gamma2 subunits reduce the mRNA for these subunits in rat brain. In this study, the effects of alpha1 and gamma2 subunit aODNs on rat alcohol preference were investigated. Reduction of the alpha1 subunit mRNA decreased, whereas reduction of the gamma2 subunit mRNA increased, ethanol intake in rats.
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