Open AccessAngiotensin II Type 2 Receptor Inhibits Vascular Intimal Proliferation With Activation of PPARγ
Author(s) -
Masayoshi Kukida,
Masaki Mogi,
Kousei Ohshima,
Hirotomo Nakaoka,
Jun Iwanami,
Harumi Kanno,
Kana Tsukuda,
Toshiyuki Chisaka,
LiJuan Min,
Xiaoli Wang,
HuiYu Bai,
BaoShuai Shan,
Akinori Higaki,
Toshifumi Yamauchi,
Takafumi Okura,
Jitsuo Higaki,
Masatsugu Horiuchi
Publication year - 2015
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1093/ajh/hpv168
Subject(s) - angiotensin ii , endocrinology , receptor , vascular smooth muscle , medicine , peroxisome proliferator activated receptor , agonist , smooth muscle
Angiotensin II type 2 (AT2) receptor stimulation could exert beneficial effects on vascular remodeling. Previously, we reported that AT2 receptor stimulation ameliorated insulin resistance in diabetic mice accompanied by PPARγ activation which also plays a variety of crucial roles in the vasculature. Therefore, this study aimed to investigate the vascular protective effect of the AT2 receptor with activation of PPARγ involving AT2 receptor-interacting protein (ATIP).
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